Article
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.
Nature genetics - 1 Jan 2018
Turcan Sevin, Makarov Vladimir, Taranda Julian, Wang Yuxiang, Fabius Armida W M, Wu Wei, Zheng Yupeng, El-Amine Nour, Haddock Sara, Nanjangud Gouri, LeKaye H Carl, Brennan Cameron, Cross Justin, Huse Jason T, Kelleher Neil L, Osten Pavel, Thompson Craig B, Chan Timothy A
Abstract excerpt
Mutations in IDH1 and IDH2 (encoding isocitrate dehydrogenase 1 and 2) drive the development of gliomas and other human malignancies. Mutant IDH1 induces epigenetic changes that promote tumorigenesis, but the scale and reversibility of these changes are unknown. Here, using human astrocyte and glioma tumorsphere systems, we generate a large-scale atlas of mutant-IDH1-induced epigenomic reprogramming. We...
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