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Article

Region-specific DNA hydroxymethylation along the malignant progression of IDH-mutant gliomas.

Cancer science - 1 May 2024

Hana Taijun, Mukasa Akitake, Nomura Masashi, Nagae Genta, Yamamoto Shogo, Tatsuno Kenji, Ueda Hiroki, Fukuda Shiro, Umeda Takayoshi, Tanaka Shota, Nejo Takahide, Kitagawa Yosuke, Yamazawa Erika, Takahashi Satoshi, Koike Tsukasa, Kushihara Yoshihiro, Takami Hirokazu, Takayanagi Shunsaku, Aburatani Hiroyuki, Saito Nobuhito

Abstract excerpt

The majority of low-grade isocitrate dehydrogenase-mutant (IDHmt) gliomas undergo malignant progression (MP), but their underlying mechanism remains unclear. IDHmt gliomas exhibit global DNA methylation, and our previous report suggested that MP could be partly attributed to passive demethylation caused by accelerated cell cycles. However, during MP, there is also active demethylation mediated by ten-eleven...

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Identifiers

PMID: 38433527
DOI: 10.1111/cas.16127
PMCID: PMC11093199

Genes

KLF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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