The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.

doi:10.1158/0008-5472.CAN-23-2093

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Article

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.

Cancer research - 4 Mar 2024

Malta Tathiane M, Sabedot Thais S, Morosini Natalia S, Datta Indrani, Garofano Luciano, Vallentgoed Wies, Varn Frederick S, Aldape Kenneth, D'Angelo Fulvio, Bakas Spyridon, Barnholtz-Sloan Jill S, Gan Hui K, Hasanain Mohammad, Hau Ann-Christin, Johnson Kevin C, Cazacu Simona, deCarvalho Ana C, Khasraw Mustafa, Kocakavuk Emre, Kouwenhoven Mathilde C M, Migliozzi Simona, Niclou Simone P, Niers Johanna M, Ormond D Ryan, Paek Sun Ha, Reifenberger Guido, Sillevis Smitt Peter A, Smits Marion, Stead Lucy F, van den Bent Martin J, Van Meir Erwin G, Walenkamp Annemiek, Weiss Tobias, Weller Michael, Westerman Bart A, Ylstra Bauke, Wesseling Pieter, Lasorella Anna, French Pim J, Poisson Laila M, Verhaak Roel G W, Iavarone Antonio, Noushmehr Houtan

Abstract excerpt

Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of...

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Identifiers

PMID: 38117484
DOI: 10.1158/0008-5472.CAN-23-2093
PMCID: PMC10911804

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