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Article

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.

Nature cancer - 1 Jan 2025

Wu Jingyi, Gonzalez Castro L Nicolas, Battaglia Sofia, El Farran Chadi A, D'Antonio Joshua P, Miller Tyler E, Suvà Mario L, Bernstein Bradley E

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress to fatal disease. To characterize their malignant cell hierarchy, we profiled chromatin accessibility and gene expression across single cells from low-grade and high-grade IDH-mutant gliomas and ascertained their developmental states through a comparison to normal brain cells. We provide...

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Brain Neoplasms
Disease Progression
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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Identifiers

PMID: 39572850
DOI: 10.1038/s43018-024-00865-3
PMCID: PMC13459074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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