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Article

DNA methylation profiling reveals a novel subtype harboring IDH mutation in H3-altered gliomas.

Neuro-oncology - 1 Jun 2026

Fu Minjie, Feng Yuan, Sun Pin, You Muyuan, Zhang Licheng, Yang Hui, Zhang Yi, Ye Dan, Wang Jiguang, Xiong Yue, Verhaak Roel, Mao Ying, Hua Wei

Abstract excerpt

BACKGROUND: H3-altered gliomas, now recognized by WHO CNS5 as grade 4 neoplasms driven by histone H3 mutations (notably H3K27M and H3G34R/V), exhibit marked molecular heterogeneity, dismal survival, and resistance to standard therapies. Despite their classification as WHO grade 4 neoplasms, current stratification fails to capture their clinical and epigenetic diversity. METHODS: We performed genome-wide DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41832962
DOI: 10.1093/neuonc/noag054
PMCID: PMC13232037

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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