Article

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

2020-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to universal therapeutic resistance. Here, we integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes, and bulk multi-omic profiles across 11 adult IDH-mutant or IDH-wild-type gliomas to delineate sources of intratumoral heterogeneity. We found that local DNA methylation ins...

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Literature Corpus work: cb539ab2-0617-5653-9828-41e2708c179d
DOI: 10.1101/2020.07.22.215335

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