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Article

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice.

ASN neuro - 1 Jan 2000

Mhatre-Winters Isha, Eid Aseel, Han Yoonhee, Tieu Kim, Richardson Jason R

Abstract excerpt

Apolipoprotein E4 (APOE4) genotype and sex are significant risk factors for Alzheimer's disease (AD), with females demonstrating increased risk modulated by APOE genotype. APOE is predominantly expressed in astrocytes, however, there is a lack of comprehensive assessments of sex differences in astrocytes stratified by APOE genotype. Here, we examined the response of mixed-sex and sex-specific neonatal APOE3 and...

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Identifiers

PMID: 36604975
DOI: 10.1177/17590914221144549
PMCID: PMC9982390

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