APOE genotype-specific differences in the innate immune response.

doi:10.1016/j.neurobiolaging.2007.11.014

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Article

APOE genotype-specific differences in the innate immune response.

Neurobiology of aging - 1 Sept 2009

Vitek Michael P, Brown Candice M, Colton Carol A

Abstract excerpt

Apolipoprotein-E protein is an endogenous immunomodulatory agent that affects both the innate and the adaptive immune responses. Since individuals with the APOE4 gene demonstrate worsened pathology and poorer outcomes in many neurological disorders, we examined isoform-specific differences in the response of microglia, the primary cellular component of the brain's innate immune response, in detail. Our data...

Topics

Animals
Animals, Newborn
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Cells, Cultured
Cerebral Cortex
Cytokines
Encephalitis
Gene Dosage
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Innate

Mice

Mice, Knockout

Mice, Transgenic

Microglia

Nitric Oxide Synthase Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 18155324
DOI: 10.1016/j.neurobiolaging.2007.11.014
PMCID: PMC2782461

Genes

APOE
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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