Article

Sex and APOE Genotype Alter the Basal and Induced Inflammatory State of Primary Microglia from APOE Targeted Replacement Mice

2022-01-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD), with females demonstrating increased risk that is modulated by APOE genotype. However, the mechanism(s) responsible for this interaction are still a matter of debate. Neuroinflammation represents a plausible mechanism for this interaction, but most experimental studies have not inc...

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Literature Corpus work: f0e67edb-985b-5c38-8749-80f8eb74d5b8
DOI: 10.21203/rs.3.rs-1281462/v1

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