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Upregulated NF-κB pathway proteins may underlie <i>APOE44</i> associated astrocyte phenotypes in sporadic Alzheimer’s disease

2023-04-20

Abstract excerpt

The Apolipoprotein-E4 allele (APOE) is the strongest genetic risk factor for sporadic Alzheimer’s disease but its role in disease pathogenesis is incompletely understood. The APOE gene encodes Apolipoprotein E (ApoE). Astrocytes are the main source of ApoE in the central nervous system (CNS) and are essential for homeostasis in health and disease. In response to CNS insult, a coordinated multicellular inflammator...

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Literature Corpus work
e0cf4af8-7dfc-54ff-87a0-9feadfd48c92
DOI
10.1101/2023.04.19.537428
Open publication

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Upregulated NF-κB pathway proteins may underlie <i>APOE44</i> associated astrocyte phenotypes in sporadic Alzheimer’s diseaseDOI 10.1101/2023.04.19.537428
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