Article

APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids

2025-05-10

Abstract excerpt

The APOE gene is a major genetic determinant of neurovascular and immune function, yet the mechanisms by which its isoforms modulate brain vulnerability to pathogenic stress remain incompletely understood. Here, we employ isogenic human iPSC-derived immune vascularized Forebrain Organoid-based Multicellular Assembled Cerebral Organoids (FORMA COs) to dissect isoform-specific responses to a clinically relevant vira...

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Literature Corpus work: 97287865-8d4f-5003-9006-bf35ffa975c1
DOI: 10.1101/2025.05.08.652864

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