Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice.

International journal of molecular sciences - 29 Aug 2022

Mhatre-Winters Isha, Eid Aseel, Han Yoonhee, Tieu Kim, Richardson Jason R

Abstract excerpt

The sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD); however, the mechanism(s) responsible for this interaction are still a matter of debate. Here, we assess the responses of mixed-sex and sex-specific APOE3 and APOE4 primary microglia (PMG) to lipopolysaccharide and interferon-gamma. In our investigation, inflammatory cytokine profiles were assessed by qPCR and multiplex ELISA...

Topics

Join the communities discussing this publication.

Alzheimer Disease
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 36077227
DOI: 10.3390/ijms23179829
PMCID: PMC9456163

Genes

APOE
IL6
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice.PMID 36077227Read ↗

Sex and APOE Genotype Alter the Basal and Induced Inflammatory State of Primary Microglia from APOE Targeted Replacement MiceSemantic proximity Read ↗

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice.Semantic proximity Read ↗

Sex steroids, APOE genotype and the innate immune system.Semantic proximity Read ↗

APOE genotype-specific differences in the innate immune response.Semantic proximity Read ↗

APOE4 confers transcriptomic and functional alterations to primary mouse microglia.Semantic proximity Read ↗

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s diseaseSemantic proximity Read ↗

Androgen-mediated immune function is altered by the apolipoprotein E gene.Semantic proximity Read ↗

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease.Semantic proximity Read ↗

Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.Semantic proximity Read ↗

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s diseaseSemantic proximity Read ↗

Early-Life Systemic Inflammation Modulate Microglia Phenotype to Slow Down Aβ Pathology in the 5xFAD Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ PlaquesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.