Sex steroids, APOE genotype and the innate immune system.

doi:10.1016/j.neurobiolaging.2004.08.001

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Article

Sex steroids, APOE genotype and the innate immune system.

Neurobiology of aging - 1 Mar 2005

Colton Carol A, Brown Candice M, Vitek Michael P

Abstract excerpt

Microglia are a primary cellular component of the CNS innate immune system. Their response to conserved pathogen motifs is inherent and leads to the release of cytoactive factors that impact surrounding neurons and glia. The microglial response is modified by the local tissue environment and by "global" factors such as gender. Exposure to estrogen and testosterone, in general, down regulate microglia and...

Topics

Animals
Apolipoproteins E
Central Nervous System
Estrogens
Female
Genotype
Humans
Macrophages
Male
Mice
Microglia
Sex Factors
Testosterone

Source

Open in PubMed

Identifiers

PMID: 15639315
DOI: 10.1016/j.neurobiolaging.2004.08.001

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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