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Article

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation.

Journal of neuroinflammation - 10 Aug 2012

Cudaback Eiron, Li Xianwu, Yang Yue, Yoo Thomas, Montine Kathleen S, Craft Suzanne, Montine Thomas J, Keene Christopher Dirk

Abstract excerpt

BACKGROUND: Inheritance of the human ε4 allele of the apolipoprotein (apo) E gene (APOE) significantly increases the risk of developing Alzheimer's disease (AD), in addition to adversely influencing clinical outcomes of other neurologic diseases. While apoE isoforms differentially interact with amyloid β (Aβ), a pleiotropic neurotoxin key to AD etiology, more recent work has focused on immune regulation in AD...

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Source

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Identifiers

PMID: 22883744
DOI: 10.1186/1742-2094-9-192
PMCID: PMC3490924

Genes

APOE
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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