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Microglial transcription profiles in mouse and human are driven by APOE4 and sex

6 Oct 2021

Abstract excerpt

Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). APOE4 is known to affect the function of microglia, but to what extent this gene drives microglial gene expression has thus far not been examined. Using a transgenic mouse model of AD that expresses human APOE, we identify a unique transcriptional profile associated with APOE4 expression. We also show a sex and...

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PMID: 34746703
DOI: 10.1016/j.isci.2021.103238

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