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Article

APOE genotype alters glial activation and loss of synaptic markers in mice.

Glia - 1 Apr 2012

Zhu Yuangui, Nwabuisi-Heath Evelyn, Dumanis Sonya B, Tai Leon M, Yu Chunjiang, Rebeck G William, LaDu Mary Jo

Abstract excerpt

The ε4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages. The mechanisms by which apoE affect diverse diseases and disorders may involve modulation of the glial response to various types of brain damage. We examined glial activation in a mouse model where each of the human APOE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22228589
DOI: 10.1002/glia.22289
PMCID: PMC3276698

Genes

APOE
PSD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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