Article
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.
Stem cell reports - 11 Jan 2022
de Leeuw Sherida M, Kirschner Aron W T, Lindner Karina, Rust Ruslan, Budny Vanessa, Wolski Witold E, Gavin Anne-Claude, Nitsch Roger M, Tackenberg Christian
Abstract excerpt
The apolipoprotein E4 (APOE4) variant is the strongest genetic risk factor for Alzheimer disease (AD), while the APOE2 allele is protective. A major question is how different APOE genotypes affect the physiology of astrocytes, the main APOE-producing brain cells. Here, we differentiated human APOE-isogenic induced pluripotent stem cells (iPSCs) (APOE4, E3, E2, and APOE knockout [APOE-KO]) to functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.