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Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

3 Oct 2022

Abstract excerpt

Recurrent seizure is a common comorbidity in early-stage Alzheimer’s disease (AD) and may contribute to AD pathogenesis and cognitive decline. Similarly, many mouse models of Alzheimer’s disease that overproduce amyloid beta are prone to epileptiform seizures that may result in early sudden death. We studied one such model, designated APP/PS1 , and found that mutation of the TAM receptor tyrosine kinase (RTK) Mer...

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PMID: 36191221
DOI: 10.1073/pnas.2204306119

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