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Article

βCTF-correlated burst of hippocampal TNFα occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Cavanagh Chelsea, Colby-Milley Jessica, Bouvier David, Farso Mark, Chabot Jean-Guy, Quirion Rémi, Krantic Slavica

Abstract excerpt

Tumor necrosis factor-alpha (TNFα) regulates neuronal excitability. We investigated whether alterations in the level of TNFα occur at a time point that precedes the reported seizure-associated hyperexcitability of hippocampal networks in pre-plaque models of Alzheimer's disease (AD). Western blot and ELISA experiments indicated a significant increase in hippocampal TNFα expression in 1-month-old TgCRND8 mice that...

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PMID: 23579326
DOI: 10.3233/JAD-122131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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