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A multimodal approach of microglial CSF1R inhibition and GENUS provides therapeutic effects in Alzheimer’s disease mice

2025-04-28

Abstract excerpt

<h4>Summary</h4> The CSF1R inhibitor PLX3397, an FDA-approved treatment for a rare cancer, has been shown to reduce microglia count, lower inflammation, and increase synaptic markers in mouse models of Alzheimer’s disease (AD). However, the effects of PLX3397 on neural function in AD remain largely unknown. Here, we characterized the effects of PLX3397 treatment in 5xFAD mice. While PLX3397 increased synaptic den...

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Literature Corpus work
89de91fa-f2b9-58e3-8f42-2a6645c022ae
DOI
10.1101/2025.04.27.648471
Open publication

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A multimodal approach of microglial CSF1R inhibition and GENUS provides therapeutic effects in Alzheimer’s disease miceDOI 10.1101/2025.04.27.648471
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