Article

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy

2020-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response in neurodegenerative diseases. Phagocytosis is very efficient in physiological conditions, as well as during apoptotic challenge induced by excitotoxicity or inflammation, but is impaired in mouse and human mesial temporal lobe epilepsy (MTLE). Here we extend our studies to a genetic model of...

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Literature Corpus work: 3a867a0d-9c37-5bf8-a8c3-fa04a86042c8
DOI: 10.1101/2020.05.06.075903

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