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Article

CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Subramanian Sandhya, Ayala Patricia, Wadsworth Teri L, Harris Christopher J, Vandenbark Arthur A, Quinn Joseph F, Offner Halina

Abstract excerpt

The inflammatory status of the brain in patients as well as animal models of Alzheimer's disease (AD) has been extensively studied. Accumulation of activated microglia producing tumor necrosis factor-α and monocyte chemotactic protein-1 contribute to the pathology of the disease. However, little is known about the changes in the spleen and associated peripheral immunity that might contribute to AD pathology. The...

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Identifiers

PMID: 20847401
DOI: 10.3233/JAD-2010-100852
PMCID: PMC2988888

Genes

CCR6

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