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Article

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

8 Oct 2021

Abstract excerpt

Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer's disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated. We suppressed epileptiform activity by treatment with the antiepileptic drug levetiracetam or by genetic ablation of tau and found that these interventions reversed or prevented aberrant...

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PMID: 34755090
DOI: 10.1016/j.isci.2021.103245

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