Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model.

Translational research : the journal of laboratory and clinical medicine - 1 Oct 2023

Chen Chunxia, Tang Xihe, Lan Zhaohui, Chen Wan, Su Hua, Li Weidong, Li Yaoxuan, Zhou Xing, Gao Hong, Feng Xinwei, Guo Ying, Yao Meicun, Deng Wenbin

Abstract excerpt

The CLU rs11136000C mutation (CLUC) is the third most common risk factor for Alzheimer's disease (AD). However, the mechanism by which CLUC leads to abnormal GABAergic signaling in AD is unclear. To address this question, this study establishes the first chimeric mouse model of CLUC AD. Examination of grafted CLUC medial ganglionic eminence progenitors (CLUC hiMGEs) revealed increased GAD65/67 and a high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Clusterin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Disease Models, Animal

Share to Mutation

Share to Receptors, GABA-A

Share to Risk Factors

Source

Identifiers

PMID: 37211336
DOI: 10.1016/j.trsl.2023.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model.PMID 37211336Read ↗

Olfactory Dysfunction and Alzheimer's Disease: A Review.Semantic proximity Read ↗

Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer disease-like cellular phenotype of newborn granule neurons can be reversed in GSK-3β-overexpressing mice.Semantic proximity Read ↗

Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.Semantic proximity Read ↗

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.Semantic proximity Read ↗

GABAA Receptor β3 Subunit Mutation N328D Heterozygous Knock-in Mice Have Lennox-Gastaut Syndrome.Semantic proximity Read ↗

Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signalingSemantic proximity Read ↗

A multimodal approach of microglial CSF1R inhibition and GENUS provides therapeutic effects in Alzheimer’s disease miceSemantic proximity Read ↗

GABAA receptor β3 subunit mutation D120N causes Lennox–Gastaut syndrome in knock-in miceSemantic proximity Read ↗

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.