Article

Impaired microglial phagocytosis promotes seizure development

2024-01-02

Abstract excerpt

In the central nervous system, triggering receptor expressed on myeloid cells 2 (TREM2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. TREM2 plays an important role in neurodegenerative diseases, such as Alzheimer’s disease and amyotrophic lateral sclerosis. However, little is known about the role TREM2 plays in epileptogenesis. To investigate this,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c976402d-e7d3-52d9-8ff6-c7bb217c09a9
DOI: 10.1101/2023.12.31.573794

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired microglial phagocytosis promotes seizure developmentDOI 10.1101/2023.12.31.573794Read

Targeting Microglial Activation in Drug-Resistant Epilepsy: Emerging Therapeutic StrategiesSemantic proximity Read

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.Semantic proximity Read

Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2Semantic proximity Read

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizuresSemantic proximity Read

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsySemantic proximity Read

Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseasesSemantic proximity Read

Mir155hg accelerates hippocampal neuron injury in convulsive status epilepticus by inhibiting microglial phagocytosisSemantic proximity Read

Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer’s Disease ModelsSemantic proximity Read

TREM2 in CNS homeostasis and neurodegenerative disease.Semantic proximity Read

TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.Semantic proximity Read

Microglia play beneficial roles in multiple experimental seizure modelsSemantic proximity Read

Cannabidiol protects against neurotoxic reactive astrocytes-induced neuronal death in mouse models of epilepsySemantic proximity Read