Article

Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse model

2020-09-22

Abstract excerpt

Microglia have an emerging role in development of tau pathology after amyloid plaque deposition in Alzheimer’s disease, although it has not been definitively shown. We hypothesize that plaque-associated activated microglia accelerate tau propagation via enhanced phagocytosis and secretion of tau. Here we show that the injection of adeno-associated virus expressing P301L tau mutant into the medial entorhinal cortex...

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Identifiers and source

Literature Corpus work: 6045d33c-f11b-57ad-9773-532fa1e4779f
DOI: 10.1101/2020.09.22.308015

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