Article

Gas6 Induces Inflammation And Reduces Plaque Burden But Worsens Behavior In The APP/PS1 Model of Alzheimer’s Disease

2021-11-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and recent evidence suggests a complex relationship between Axl, Mer, and microglial phagocytosis of amyloid plaques in AD. Gas6, the primary CNS TAM ligand, reduc...

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Literature Corpus work: 675f1179-6ca4-59aa-8400-734e29dd86e2
DOI: 10.21203/rs.3.rs-991983/v1

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