Morphological and functional differences between hippocampal and cortical microglia and its impact on neuronal over-excitation in a germline Pten mutant mouse model.

Abstract excerpt

High-throughput, transcriptomic analyses of the brain have revealed significant differences of microglia between the hippocampus and the cortex. However, it remains unclear whether these regional differences translate into different microglial behaviors and impact disease progression. Here, we show that microglia possess higher morphological complexity and phagocytic capacity in the hippocampus compared to the...

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