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Suppression of MT5-MMP reveals early modulation of Alzheimer’s pathogenic events in primary neuronal cultures of 5xFAD mice

2024-02-16

Abstract excerpt

<h4>Background: </h4> We previously reported that membrane-type 5-matrix metalloproteinase (MT5-MMP) deficiency not only reduces pathological hallmarks of Alzheimer’s disease (AD) in 5xFAD (Tg) mice in vivo, but also impairs interleukin-1 beta (IL-1β)-mediated neuroinflammation and Ab production in primary Tg immature neural cell cultures after 11 days in vitro. We now investigated the effect of MT5-MMP on incipie...

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Literature Corpus work
5f6de011-e556-50f6-b404-d68765d4adc3
DOI
10.21203/rs.3.rs-3910332/v1
Open publication

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Suppression of MT5-MMP reveals early modulation of Alzheimer’s pathogenic events in primary neuronal cultures of 5xFAD miceDOI 10.21203/rs.3.rs-3910332/v1
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