Article
Homeostasis limits keratinocyte evolution.
Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2022
Schenck Ryan O, Kim Eunjung, Bravo Rafael R, West Jeffrey, Leedham Simon, Shibata Darryl, Anderson Alexander R A
Abstract excerpt
Recent studies have revealed that normal human tissues accumulate many somatic mutations. In particular, human skin is riddled with mutations, with multiple subclones of variable sizes. Driver mutations are frequent and tend to have larger subclone sizes, suggesting selection. To begin to understand the histories encoded by these complex somatic mutations, we incorporated genomes into a simple agent-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.