Article
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.
Science (New York, N.Y.) - 22 May 2015
Martincorena Iñigo, Roshan Amit, Gerstung Moritz, Ellis Peter, Van Loo Peter, McLaren Stuart, Wedge David C, Fullam Anthony, Alexandrov Ludmil B, Tubio Jose M, Stebbings Lucy, Menzies Andrew, Widaa Sara, Stratton Michael R, Jones Philip H, Campbell Peter J
Abstract excerpt
How somatic mutations accumulate in normal cells is central to understanding cancer development but is poorly understood. We performed ultradeep sequencing of 74 cancer genes in small (0.8 to 4.7 square millimeters) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals, the burden of somatic mutations averaged two to six mutations per megabase per cell, similar to that...
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