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Article

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma

2024-07-24

Abstract excerpt

We performed multi-omic profiling of epidermal keratinocytes, precancerous actinic keratoses, and squamous cell carcinomas to understand the molecular transitions during skin carcinogenesis. Single-cell mutational analyses of normal skin cells showed that most keratinocytes have remarkably low mutation burdens, despite decades of sun exposure, however keratinocytes with TP53 or NOTCH1 mutations had substantially...

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Identifiers and source

Literature Corpus work
4dd7ca82-4dbd-537c-a6ba-e970f85f0f15
DOI
10.1101/2024.07.23.604673
Open publication

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Genetic evolution of keratinocytes to cutaneous squamous cell carcinomaDOI 10.1101/2024.07.23.604673
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