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Article

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease.

Molecular oncology - 1 Sept 2022

Marongiu Fabio, DeGregori James

Abstract excerpt

Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer-associated mutations in an aging-dependent fashion. Additional studies show how aged tissue microenvironments promote the initiation and progression of malignancies, while young healthy tissues actively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35726685
DOI: 10.1002/1878-0261.13275
PMCID: PMC9490148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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