Article
Somatic mutations distinguish melanocyte subpopulations in human skin.
Nature cell biology - 1 Jun 2026
Tandukar Bishal, Deivendran Delahny, Chen Limin, Bahrani Neda, Baskurt Defne, Weier Beatrice, Sharma Harsh, Cruz-Pacheco Noel, Hu Min, Marks Kayla, Zitnay Rebecca G, Bandari Aravind K, Rentroia-Pacheco Barbara, Nekoonam Rojina, Bastian Boris C, Yeh Iwei, Judson-Torres Robert, Shain A Hunter
Abstract excerpt
Here, to understand the homeostatic mechanisms governing melanocytes, we interrogate the mutational landscapes, gene-expression profiles and morphological features of 297 clonal expansions of epidermal melanocytes from 31 donors. We show that a population of melanocytes with low mutation burden persists in sun-exposed epidermis. These cells are smaller, less dendritic, and exhibit stem-like expression profiles...
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