A modelling framework for cancer ecology and evolution.

Abstract excerpt

Cancer incidence increases rapidly with age, typically as a polynomial. The somatic mutation theory explains this increase through the waiting time for enough mutations to build up to generate cells with the full set of traits needed to grow without control. However, lines of evidence ranging from tumour reversion and dormancy to the prevalence of presumed cancer mutations in non-cancerous tissues argue that this...

Topics

• Humans
• Neoplasms
• Models, Biological
• Mutation
• Models, Genetic