Article
A body map of somatic mutagenesis in morphologically normal human tissues.
Nature - 1 Sept 2021
Li Ruoyan, Di Lin, Li Jie, Fan Wenyi, Liu Yachen, Guo Wenjia, Liu Weiling, Liu Lu, Li Qiong, Chen Liping, Chen Yamei, Miao Chuanwang, Liu Hongjin, Wang Yuqian, Ma Yuling, Xu Deshu, Lin Dongxin, Huang Yanyi, Wang Jianbin, Bai Fan, Wu Chen
Abstract excerpt
Somatic mutations that accumulate in normal tissues are associated with ageing and disease1,2. Here we performed a comprehensive genomic analysis of 1,737 morphologically normal tissue biopsies of 9 organs from 5 donors. We found that somatic mutation accumulations and clonal expansions were widespread, although to variable extents, in morphologically normal human tissues. Somatic copy number alterations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.