Article

A body map of somatic mutagenesis in morphologically normal human tissues

2020-12-01

Abstract excerpt

Somatic mutations accumulated in normal tissues are associated with aging and disease. Here, we performed a comprehensive genomic analysis of 1,737 morphologically normal tissue biopsies (~ 600 cells each), mostly from the epithelia, of nine organs from five donors. We found that somatic mutation accumulations and clonal expansions are widespread, although with variable extent, in morphologically normal human tiss...

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Literature Corpus work: 036ee134-c23d-59a0-a671-0f766a576824
DOI: 10.1101/2020.11.30.403436

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