Article
Clonal Architecture of the Epidermis: Homeostasis Limits Keratinocyte Evolution
2019-02-14
Abstract excerpt
The skin is the largest human organ, functioning to serve as the protective barrier to the harsh, outside world. Recent studies have revealed that large numbers of somatic mutations accumulate in normal tissue, which can be used to infer skin cell dynamics 1-5 . Here we present the first realistic, cell-genome mechanistic epidermal model that shows homeostasis imposes a characteristic log-linear subclone size dis...
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Identifiers and source
- Literature Corpus work
- 7066cce8-d132-5334-9c33-ca2847649f4d
- DOI
- 10.1101/548131