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Article

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

27 Sept 2018

Abstract excerpt

Aging human tissues, such as sun-exposed epidermis, accumulate a high burden of progenitor cells that carry oncogenic mutations. However, most progenitors carrying such mutations colonize and persist in normal tissue without forming tumors. Here, we investigated tissue-level constraints on clonal progenitor behavior by inducing a single-allele p53 mutation ( Trp53 R245W ; p53 ∗/wt ), prevalent in normal human...

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PMID: 30269904
DOI: 10.1016/j.stem.2018.08.017

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