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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

6 Jun 2019

Abstract excerpt

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 normal tissues revealed multiple somatic variants, demonstrating that macroscopic clones can be found in many normal tissues. We found that sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests that environmental...

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PMID: 31171663
DOI: 10.1126/science.aaw0726

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