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Article

Mutational Landscape of Normal Human Skin: Clues to Understanding Early-Stage Carcinogenesis in Keratinocyte Neoplasia.

The Journal of investigative dermatology - 1 Jul 2023

Kim Yoon-Seob, Bang Chul Hwan, Chung Yeun-Jun

Abstract excerpt

Normal skin contains numerous clones carrying cancer driver mutations. However, the mutational landscape of normal skin and its clonal relationship with skin cancer requires further elucidation. The aim of our study was to investigate the mutational landscape of normal human skin. We performed whole-exome sequencing using physiologically normal skin tissues and the matched peripheral blood (n = 39) and...

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Carcinogenesis
DNA Mutational Analysis
Exome Sequencing
Keratinocytes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36716918
DOI: 10.1016/j.jid.2023.01.006

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