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Article

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.

Life science alliance - 1 Nov 2022

Bardwell A Jane, Wu Beibei, Sarin Kavita Y, Waterman Marian L, Atwood Scott X, Bardwell Lee

Abstract excerpt

Crosstalk between the Hedgehog and MAPK signaling pathways occurs in several types of cancer and contributes to clinical resistance to Hedgehog pathway inhibitors. Here we show that MAP kinase-mediated phosphorylation weakens the binding of the GLI1 transcription factor to its negative regulator SUFU. ERK2 phosphorylates GLI1 on three evolutionarily conserved target sites (S102, S116, and S130) located near the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35831023
DOI: 10.26508/lsa.202101353
PMCID: PMC9279676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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