Article
Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.
PloS one - 1 Jan 2016
Urman Nicole M, Mirza Amar, Atwood Scott X, Whitson Ramon J, Sarin Kavita Y, Tang Jean Y, Oro Anthony E
Abstract excerpt
The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC). The majority of BCCs arise from mutations in the Patched receptor resulting in constitutive activation of the Hedgehog pathway. Secondary driver mutations promote BCC oncogenesis and occur frequently due to the high mutational burden resulting from sun...
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