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Article

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2010

Sun Minghao, Hillmann Petra, Hofmann Bianca T, Hart Jonathan R, Vogt Peter K

Abstract excerpt

Cancer-specific mutations in the iSH2 (inter-SH2) and nSH2 (N-terminal SH2) domains of p85alpha, the regulatory subunit of phosphatidylinositide 3-kinase (PI3K), show gain of function. They induce oncogenic cellular transformation, stimulate cellular proliferation, and enhance PI3K signaling. Quantitative determinations of oncogenic activity reveal large differences between individual mutants of p85alpha. The...

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Identifiers

PMID: 20713702
DOI: 10.1073/pnas.1009652107
PMCID: PMC2932613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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