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Article

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.

Genes & development - 15 Nov 2014

Lin Chuwen, Yao Erica, Wang Kevin, Nozawa Yoko, Shimizu Hirohito, Johnson Jeffrey R, Chen Jau-Nian, Krogan Nevan J, Chuang Pao-Tien

Abstract excerpt

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the nucleus, highlighting critical functions of Sufu in the nucleus. Through a proteomic approach, we identified several...

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Identifiers

PMID: 25403183
DOI: 10.1101/gad.249425.114
PMCID: PMC4233246

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