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Article

Role and regulation of human tumor suppressor SUFU in Hedgehog signaling.

Advances in cancer research - 1 Jan 2008

Cheng Steven Y, Yue Shen

Abstract excerpt

Originally identified as factors affecting Drosophila embryogenesis, the Hedgehog (Hh) pathway is one of the primary signaling systems that specify patterns of cell growth and differentiation during vertebrate development. Mutations in various components of this pathway frequently occur in tumors originated from the skin, cerebellum, and skeletal muscle, and abnormal pathway activity is associated with a subset...

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Share to Drosophila
Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19055941
DOI: 10.1016/S0065-230X(08)00402-8

Genes

SUFU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role and regulation of human tumor suppressor SUFU in Hedgehog signaling.PMID 19055941Read ↗

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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.Semantic proximity Read ↗

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.Semantic proximity Read ↗

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulationSemantic proximity Read ↗

Loss of suppressor-of-fused function promotes tumorigenesis.Semantic proximity Read ↗

Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3.Semantic proximity Read ↗

Loss of SUFU function in familial multiple meningioma.Semantic proximity Read ↗

The FU gene and its possible protein isoforms.Semantic proximity Read ↗

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesisSemantic proximity Read ↗

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