Article

AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin syndrome patients

2026-01-07

Abstract excerpt

The tumor suppressor SUFU is a key negative regulator of oncogenic GLI transcription factors. SUFU mutations predispose to medulloblastoma and can cause Gorlin and Joubert syndromes. Limited structural information is available on the GLI-SUFU complex, contributing to the fact that the vast majority of SUFU missense variants sequenced from affected patients are of unknown clinical significance. Using AlphaFold3 a...

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Literature Corpus work: 319c8b8b-ca33-51e0-8e8e-4debc0b09c32
DOI: 10.64898/2026.01.06.698042

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