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Article

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

Nature communications - 1 Jan 2013

Zhang Yan, Fu Lin, Qi Xiaolong, Zhang Zhenyi, Xia Yuanxin, Jia Jianhang, Jiang Jin, Zhao Yun, Wu Geng

Abstract excerpt

Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, especially in mammals. Here structures of full-length human and Drosophila Sufu, the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24217340
DOI: 10.1038/ncomms3608
PMCID: PMC5842692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.PMID 24217340Read ↗

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Characterization of the human Suppressor of fused, a negative regulator of the zinc-finger transcription factor GliSemantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.Semantic proximity Read ↗

A large disordered region confers a wide spanning volume to vertebrate Suppressor of Fused as shown in a trans-species solution studySemantic proximity Read ↗

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesisSemantic proximity Read ↗

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.Semantic proximity Read ↗

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