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Article

Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions.

The Journal of biological chemistry - 1 Apr 2025

Torres Robles Jaylissa, Stiegler Amy L, Boggon Titus J, Turk Benjamin E

Abstract excerpt

The protein kinase ERK2 is recurrently mutated in human squamous cell carcinomas and other tumors. ERK2 mutations cluster in an essential docking recruitment site that interacts with short linear motifs found within intrinsically disordered regions of ERK substrates and regulators. Cancer-associated mutations do not disrupt ERK2 docking interactions altogether but selectively inhibit some interactions while...

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Identifiers

PMID: 40015635
DOI: 10.1016/j.jbc.2025.108348
PMCID: PMC11982978

Genes

ARHGEF2
ISG20

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