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Article

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

4 Oct 2012

Abstract excerpt

Abnormal activation of Hedgehog (Hh) signaling leads to basal cell carcinoma (BCC) of the skin, the most common human cancer. Gli2, the major transcriptional activator of Hh signaling, is essential for hair follicle development and its overexpression in epidermis induces BCC formation and maintains tumor growth. Despite its importance in skin development and tumorigenesis, little is known about the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23034632
DOI: 10.1242/dev.081190

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